ABSTRACT
In the current study the influence of
administration of monosodium glutamate (MSG) on temporal lobe, body weight
and enzyme activity in adult wistar rat was studied. As well as the
role of ascorbic acid (Vitamin-C) in the prevention of MSG-induced alteration
in the temporal cortex.
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The experimental
animals were randomly allotted into six groups. The group A was the normal
control group and the animals of this groups remained in their home cage
throughout the experimental period. They received rat chow and and distilled
water only for the entire duration of the experiment.
The group B was
treated with MSG only at the dose of 4mg/kg per b.w for 28days. Those in group
C and D were given vitamin C only with doses of 51mg/kg b.w (Low dose) and
105mg/kg b.w (High dose) respectively for 28days. The group E and F were orally
administered with aqueous solution of vitamin C solution dose of 51mg/kg b.w (Low dose) and 105mg/kg b.w (High
dose) respectively, followed by aqueous solution of MSG 4mg/kg b.w.
MSG had adverse effect
on the temporal lobe. As a result all adverse effect were significantly
prevented by the simultaneous administration of ascorbic acid with MSG. There
was increase in mean weight after treatment in following groups: Control group and Group A. The mean
weight in group B and E showed reduction
in mean weight after administration. Mean weights in Group C and D was maintained as
before administration. There was a slight increase in the serum level
of ALP in four of the treated groups with statistical significance (P <
0.05) as compared with control group. There was an increase in the serum level
of the AST in all the treated groups with statistical significance (P<0 .05="" all="" alt="" an="" as="" compared="" control="" group.="" groups="" in="" increase="" level="" o:p="" of="" serum="" significance="" statistical="" the="" there="" treated="" was="" with="">
The present data point to the neuro-protective
role of ascorbic acid. The ascorbic acid can serve as an anti-oxidant to
neutralize the adverse effect of MSG and can also be useful as a therapeutic
agent in various brain defect.
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