IRON OXIDE NANOPARTICLES

Iron oxide nanoparticles can be used for medical imaging, disease diagnosis, drug delivery, cancer treatment, gene therapy and other cases. These particles accumulate in liver cells and lead to oxidative stress with generation of reactive oxygen species. 

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This research is aimed at investigating the adverse effect of ferrous oxide nanoparticles on liver of wistar rats. In this research 35 male wistar rats were used for experiment, and they were grouped into four groups. One group was control and other three experimental groups were exposed to ferrous oxide nanoparticle at different exposure (24hours, 48hours and 72 hours).

All the experimental animals were sacrificed by cervical dislocation. Immediately after the experimental animals were sacrificed, they were dissected and the liver was harvested and fixed in 10% Formosaline. The tissues were later processed for histological techniques and stained with hematoxylin and eosin (H&E). The histological analysis of control group shows normal sinusoids, hepatocytes, central vein. The result reveals that the administration of ferrous oxide nanoparticle affects the sinusoids, central vein and the hepatocytes. It also showed hemorrhage on the central vein, necrosis, disorganized sinusoids, deformed bile duct, ruptured hepatic artery and damaged hepatocytes. The result of this research reveals that ferrous oxide nanoparticles affects the liver and causes severe damage to the liver. Also there was weight decrease after administration of the experimental animals.