This
study is aimed at investigating the effect of ferrous oxide nanoparticles on
testis of wistar rats. In this research 35 wistar rats were used as
experimental animals, grouped into four and designated as 24hours, 48hours,
72hours and control were acclimatized for two weeks.
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| Source: english.farsnews.com |
After acclimatization,
each group of the experimental animals was sub-divided into 5 low dose and 5
high dose except the control. 30 wistar rats were administered intravenously at
low dose of 5mg/kg and high dose of 10mg/kg while the 5 control had access to
only feeds and water. The histological analysis of the testis of control group
shows normal seminiferous tubules, spermatogonia, sertoli cells and leydigs
cells. The result reveals that the administration of ferrous oxide nanoparticle
affects the seminiferous tubules, spermatogonia, sertoli cells, lumen of the
seminiferous tubules, basement membrane and leydig cells of most of the groups
especially at high dose. The result of low dose of 24hours and 48hours group
shows scanty sertoli cells, some deformed seminiferous tubules and few
spermatogonia. The result of high dose
of 24hours, 48hours, 72hours and low dose of 72hours group shows highly
deformed seminiferous tubules, distorted basement membrane, enlarged lumen of
the seminiferous tubules and degenerating germ cells. There is hemorrhage in
the seminiferous tubules of 48hours high dose group. The result of this study
reveals that the administration of ferrous oxide nanoparticles affects the
testis and will reduce fertility.
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